Glioblastoma: multicentric

Case contributed by Dr Ahmed Abd Rabou


Headache, vertigo and recurrent vomiting. Previous MRI revealed multiple SOL and biopsy was taken from the largest one

Patient Data

Age: 60-year-old
Gender: Female

MRI Brain

Modality: MRI

There are multiple variable size and shape intraaxial space occupying lesions seen at left frontal, right and left parietal lobes. The largest lesion is seen at right parietal region and extends through the splenium of the corpus callosum to the opposite side, it also shows intratumoral hemorrhage from previous biopsy as well as extracranial herniation through a craniotomy defect. All lesions display marginal enhancement after contrast administration.

Case Discussion

Histopathology of the largest lesion revealed WHO grade IV glioblastoma with pleomorphic astrocytes and marked atypia and mitotic figures. The frontal lesion does not appear to be connected to the occipital lesions by abnormal T2 signal, and thus the term multicentric glioblastoma would be favoured over multifocal. 

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Case Information

rID: 36599
Case created: 1st May 2015
Last edited: 11th Dec 2015
Inclusion in quiz mode: Included

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