Glioblastoma (multifocal)

Case contributed by A.Prof Frank Gaillard

Presentation

Seizures and left sided weakness.

Patient Data

Age: 70
Gender: Female
Modality: MRI

Three peripherally enhancing lesions extend in a row from right to left, with the central lesion within the corpus callosum. They are embedded in a continuous region of high T2 signal. The enhancing component demonstrates diffusion restriction similar to normal white matter (~700 x 10-6 mm2/sec). The right sided lesion has evidence of haemorrhage on gradient echo. 

Case Discussion

Although the presence of three discrete enhancing lesions would make one naturally think of metastases, there are a few features that enable you to make the diagnosis of GBM pre-operatively with confidence. 

  1. the three lesions are in a line, along crossing white matter tracts
  2. the middle lesion is within the corpus callosum, a very unusual location for a metastasis

The patient went on to have a craniotomy and resection of the right sided lesion, confirming that this does indeed represent a GBM. 

Histology

MICROSCOPIC DESCRIPTION:

Paraffin sections show fragments of a densely hypercellular astrocytic glioma. Tumour cells show moderate nuclear and cellular pleomorphism. Frequent mitotic figures are identified as well as foci of microvascular proliferation. There is also confluent and palisaded necrosis. Some areas of necrosis incorporate thin-walled necrotic and thrombosed blood vessels. The features are of glioblastoma multiforme (WHO grade IV). Neither oligodendroglioma or primitive neuroectodermal tumour components are identified.

IMMUNOHISTOCHEMISTRY:

  • GFAP positive
  • Nestin positive
  • IDH-1 R132H negative (not mutated)
  • MGMT negative (likely unmethylated)
  • p53 positive
  • p16 negative
  • Topoisomerase labelling index: Approximately 15%

FINAL DIAGNOSIS:

Glioblastoma (WHO Grade IV)

Note:

As the three foci of enhancement are along a dominant white matter tract, even if definite T2 bridging signal abnormality could not be identified (in this case there is definite bridging T2 signal change), it should still be considered multifocal rather than multicentric disease. 

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Case Information

rID: 33042
Case created: 29th Dec 2014
Last edited: 29th Mar 2017
Inclusion in quiz mode: Included

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