Glioblastoma NOS

Case contributed by Assoc Prof Frank Gaillard


Adult patient with increasing headache.


MRI Brain (selected images)

MRI demonstrates a large mass in the superior part of the right temporal lobe. It exerts significant mass effect and is surrounded by vasogenic edema. The mass itself is heterogeneously low on T1, and demonstrates a very high T2 signal region centrally, suggestive of a necrotic center. 

Following administration of contrast, the margins enhance irregularly. 

Features are most consistent with a high-grade (WHO grade IV) primary glial tumor. 

Case Discussion

Biopsy confirmed this to be a glioblastoma.

Note: This case predates the recent (2016) revision WHO classification of CNS tumors and IDH status is not available. As such, this tumor would now be classified as a glioblastoma NOS.

PlayAdd to Share

Case information

rID: 8939
Published: 10th Mar 2010
Last edited: 13th Aug 2019
Tag: gbm, glioma
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.