Glioblastoma NOS

Case contributed by A.Prof Frank Gaillard


Adult patient with increasing headache.


MRI Brain (selected images)

MRI demonstrates a large mass in the superior part of the right temporal lobe. It exerts significant mass effect and is surrounded by vasogenic oedema. The mass itself is heterogeneously low on T1, and demonstrates a very high T2 signal region centrally, suggestive of a necrotic centre. 

Following administration of contrast, the margins enhance irregularly. 

Features are most consistent with a high-grade (WHO grade IV) primary glial tumour. 

Case Discussion

Biopsy confirmed this to be a glioblastoma.

Note: This case predates the recent (2016) revision WHO classification of CNS tumours and IDH status is not available. As such, this tumour would now be classified as a glioblastoma NOS.

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Case information

rID: 8939
Published: 10th Mar 2010
Last edited: 21st May 2017
Tag: gbm, glioma
Inclusion in quiz mode: Included

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