Glioblastoma NOS

Case contributed by A.Prof Frank Gaillard


Sudden onset headache and reduced level of consciousness.

Patient Data

Age: 35 years
Gender: Female

A large heterogenous haemorrhagic mass in the left thalamus is present with marked non-communicating hydrocephalus. 


A large left thalamic mass is present with heterogeneous enhancement and central non-enhancement. Haemorrhagic components result in blooming. Ventricles have reduced in size and a craniotomy is now present. 

In a young patient in addition to a high grade glioma (GBM), which is the most likely diagnosis, one could entertain a pilocytic astrocytoma or less likely a metastases. 

Case Discussion

The patient went on to have a biopsy and third ventriculostomy (between CT and MRI) which confirmed the diagnosis of glioblastoma multiforme (GBM)

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS

PlayAdd to Share

Case information

rID: 8771
Published: 17th Apr 2016
Last edited: 21st May 2017
Inclusion in quiz mode: Included

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.