Glioblastoma NOS

Case contributed by Dr Bruno Di Muzio

Presentation

Seizure.

Patient Data

Age: 60 years
Gender: Male
CT

CT Brain

There is a right parietal lobe lobulated and heterogeneous mass which shows necrotic central areas and peripheral enhancement after contrast administration. It causes also local mass effect compressing the right lateral ventricle and with a mild left midline shift. 

MRI

MRI Brain

The lesion is now better demonstrated as involving the right portion of the splenium of the corpus callosum, posterior portion of the cingulate gyrus and part of precuneus. Ir relatively spared the cortex. Small foci of blooming artefact on the gradient express minor haemorrhagic component. Contrast enhancement is again demonstrated, and the tumour shows also diffusion restriction. 

Case Discussion

The features demonstrated on the MRI helps to put a glioblastoma as the first hypothesis. Glioblastomas have a preferential spreading along the condensed white matter tracts such as corticospinal tracts and corpus callosum.

The case was histologically confirmed as glioblastoma (WHO grade IV). 

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS.

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Case information

rID: 39641
Case created: 13th Sep 2015
Last edited: 22nd May 2017
Tag: rmh
Inclusion in quiz mode: Included

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