Glioblastoma NOS

Case contributed by Dr Hani Salam

Presentation

Headaches.

Patient Data

Age: 30 years
Gender: Female
MRI

Large heterogeneously enhancing mass with regions of peripheral nodularity. The adjacent cortex is thickened. Marked elevation of choline. 

Case Discussion

The patient went on to have a resection which confirmed the diagnosis of glioblastoma.

Histology

  • Neoplastic cells positive for GFAP (polyclonal)
  • Negative for EMA
  • Strong nuclear staining for P53 (D0-7)
  • Ki-67 positive in 15%

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS.

PlayAdd to Share

Case information

rID: 12502
Case created: 4th Dec 2010
Last edited: 22nd May 2017
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.