Glioblastoma NOS

Case contributed by Dr Hani Salam



Patient Data

Age: 30 years
Gender: Female

Large heterogeneously enhancing mass with regions of peripheral nodularity. The adjacent cortex is thickened. Marked elevation of choline. 

Case Discussion

The patient went on to have a resection which confirmed the diagnosis of glioblastoma.


  • Neoplastic cells positive for GFAP (polyclonal)
  • Negative for EMA
  • Strong nuclear staining for P53 (D0-7)
  • Ki-67 positive in 15%

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS.

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Case information

rID: 12502
Published: 4th Dec 2010
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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