Glioblastoma NOS

Case contributed by A.Prof Frank Gaillard

Presentation

Headaches.

Patient Data

Age: 55 years
Gender: Male
MRI

Ring-enhancing mass in the right temporo-parietal region. Some nodular componenets. Surrounding oedema. Blooming on GRE indicative of intralesional haemorrhage. 

Case Discussion

The patient went on to have surgery. 

Histology

The biopsy shows a moderately cellular astrocytic tumour.  The astrocytes have enlarged elongated and hyperchromatic nuclei.  These are admixed with scattered foamy macrophages.  Mitoses are identified. There are foci of endothelial cell hyperplasia.  Necrosis is also seen, along with necrotic blood vessels.  The features are those of glioblastoma multiforme.

FINAL DIAGNOSIS: glioblastoma

 

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 10223
Case created: 24th Jul 2010
Last edited: 31st May 2017
Tag: glioma
Inclusion in quiz mode: Included

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