Glioblastoma NOS

Case contributed by Ahmed Abdrabou


Left hemiparesis and headache

Patient Data

Age: 80 years
Gender: Male

MRI Brain


Right parietooccipital irregular intra-axial heterogeneous lesion surrounded by perifocal edema and exerting a positive mass effect on the ipsilateral lateral ventricle. It displays heterogeneous enhancement with a hemorrhagic component at the posterior aspect of this lesion.

Magnetic resonance spectroscopy reveals:

  • reduced NAA reflecting neuronal damage
  • elevated choline denoting rapid membrane turnover
  • marked lipid and lactate rise indicating intralesional necrosis

Case Discussion

The case was confirmed histologically.

Glioblastoma is a highly malignant primary brain tumor (WHO IV) and represents the most common primary malignant brain tumor.

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS

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