Glioblastoma NOS

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
MRI

A larger left frontal lobe peripherally enhancing mass with central non-enhancement (suggesting necrosis) is present. It is surrounded by oedema and exerts positive mass effect. 

Case Discussion

 

The patient went on to have surgery. 

Histology

Microscopic Description:

Sections show the specimen to consist predominantly of necrotic tissue, in areas containing viable glioma that is high grade. The tumour cells display small cell morphologic characteristics, possible oligodendroglial features, and astrocytic elements with a fibrillar appearance. Mitotic figures are identified. Vascular proliferation is observed, including glomeruloid aggregates of proliferating capillaries. As previously mentioned, tumour necrosis is extensive. Abnormally large ectatic vascular structures are also seen and are consistent with a vascular malformation. Several vessels are thrombosed.

Final diagnosis: glioblastoma

Note: This case predates the recent (2016) revision WHO classification of CNS tumours and IDH status is not available. As such, this tumour would now be classified as a glioblastoma NOS.

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Case information

rID: 5292
Case created: 31st Dec 2008
Last edited: 29th Jun 2017
Inclusion in quiz mode: Included

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