Loading Stack -
0 images remaining
A larger left frontal lobe peripherally enhancing mass with central non-enhancement (suggesting necrosis) is present. It is surrounded by oedema and exerts positive mass effect.
The patient went on to have surgery.
Sections show the specimen to consist predominantly of necrotic tissue, in areas containing viable glioma that is high grade. The tumour cells display small cell morphologic characteristics, possible oligodendroglial features, and astrocytic elements with a fibrillar appearance. Mitotic figures are identified. Vascular proliferation is observed, including glomeruloid aggregates of proliferating capillaries. As previously mentioned, tumour necrosis is extensive. Abnormally large ectatic vascular structures are also seen and are consistent with a vascular malformation. Several vessels are thrombosed.
Final diagnosis: glioblastoma
Note: This case predates the recent (2016) revision WHO classification of CNS tumours and IDH status is not available. As such, this tumour would now be classified as a glioblastoma NOS.