Glioblastoma NOS

Case contributed by Dr Prashant Gupta


headache of long standing duration

Patient Data

Age: 50
Gender: Male

MRI showed a rim enhancing necrotic mass in left parieto-occipital region with significant surrounding edema.

Note that the edema crosses the splenium of corpus callosum.


Spectroscopy was done at the rim of the leison and showed elevated cho/cr ratio, however the ratio was not grossly elevated, further prominent lipid/lactate peaks were found and the Cho/NAA ratio was reduced and not increased as one would expect. 

This feature confounded the diagnosis of a glioma, tuberculoma can show mildly elevated cho/Cr and shows prominent lipid/lactate peaks. Tumefactive demyelination can have a similar picture as well.


Perfusion imaging was done to further characterize the lesion. It showed a raised rCBV value of 3.35 compared to contralateral normal brain.

Case Discussion

The operative findings, in this case, revealed a necrotic whitish mass. Histopathology revealed a glioblastoma.

Perfusion can be used as a problem-solving technique in equivocal cases as well as to confirm radiological suspicion

It can be integrated into an algorithm as given in the excellent article quoted below.


Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 18860
Published: 25th Jul 2012
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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