Presentation
Headache and seizure attacks.
Patient Data
Abnormal signal intraaxial solid thick irregular rim enhancing mass measuring about 30*35*40 mm with necrotic center at left parietal lobe surrounded by marked vasogenic edematous changes
The mass shows water restriction on DWI images
Colpocephaly of the left lateral ventricle occipital horn
Empty sella.
Case Discussion
The mass was biopsied and histopathologic examination revealed:
Microscopic description: Neoplasm with fibrillar background arranged in sheets. The neoplastic cells are large pleomorphic having moderate cytoplasm, pleomorphic hyperchromatic nuclei, and coarse chromatin. Increased mitotic figures are noted. Foci showing microvascular proliferation and necrosis.
Diagnosis: Glioblastoma multiform WHO grade IV.