Glioblastoma NOS (butterfly morphology)

Case contributed by A.Prof Frank Gaillard


Headache and personality change.

Patient Data

Age: 80 years
Gender: Female

CT brain

Extensive bifrontal tumour involving the corpus callosum associated with moderate vasogenic oedema.

Case Discussion

Typical appearances of a butterfly glioma. The patient went on to have a biopsy. 


MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a densely hypercellular glial tumour.  Tumour cells are a mixture of fibrillary and gemistocytic astrocytes and several markedly pleomorphic multinucleated tumour giant cells are also noted.  Scattered mitotic figures are identified. There are foci of necrosis as well as microvascular proliferation with endothelial cell hyperplasia.  

FINAL DIAGNOSIS: Glioblastoma (WHO Grade IV).


Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS


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Case information

rID: 23097
Published: 22nd May 2013
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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