Glioblastoma NOS (butterfly morphology)

Case contributed by Assoc Prof Frank Gaillard


Headache and personality change.

Patient Data

Age: 80 years
Gender: Female

CT brain

Extensive bifrontal tumor involving the corpus callosum associated with moderate vasogenic edema.

Case Discussion

Typical appearances of a butterfly glioma. The patient went on to have a biopsy. 


MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a densely hypercellular glial tumor.  Tumor cells are a mixture of fibrillary and gemistocytic astrocytes and several markedly pleomorphic multinucleated tumor giant cells are also noted.  Scattered mitotic figures are identified. There are foci of necrosis as well as microvascular proliferation with endothelial cell hyperplasia.  

FINAL DIAGNOSIS: Glioblastoma (WHO Grade IV).


Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS


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Case information

rID: 23097
Published: 22nd May 2013
Last edited: 4th Jun 2020
Inclusion in quiz mode: Included

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