Glioblastoma NOS (large cystic component)

Case contributed by Dr Yune Kwong


Referral from another institution for pre-surgical imaging.

Patient Data

Age: 60 years
Gender: Male

MRI Brain (selected images)

Large right temporal cystic/solid lesion with mass effect and compression of the right cerebral peduncle. Marginal rim enhancement around the margins of the cystic component. Solid elements on lateral margin, which enhance poorly and do not exhibit restricted diffusion.

The patient went on to have a resection.


MICROSCOPIC DESCRIPTION: A cellular infiltrate displaying variable nuclear hyperchromasia, angularity and pleomorphism, frequent mitotic figures and scant cell bodies, accompanied by a delicate fibrillary matrix which in part has a mucoid quality. Accompanied by a rich vasculature,   including thrombosis,   perivascular hyalinization and swelling and stratification of endothelium, the infiltrate is diffuse but for foci of palisading around occasional blood vessels or zones of necrosis. The lesion appears to reach the subarachnoid space.  Part of the internal margin of the growth is present as a blurred interface with adjacent brain tissue.

FINAL DIAGNOSIS: glioblastoma.

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 29580
Published: 6th Jun 2014
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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