Glioblastoma NOS - large cystic component

Case contributed by Dr Mostafa Mahmoud El-Feky


Headache and seizures.

Patient Data

Age: 60 years
Gender: Male

MRI Brain

Intra-axial space occupying lesion measuring 7 cm in diameter, noted involving the cortex, subcortical and deep white matter regions at the left frontal lobe, extending to the genu of corpus callosum and showing modest extension to the contralateral region. It is T1 hypointense, T2 hyperintense with peripheral ring enhancement and enhancing mural nodule at the inferior aspect. Blooming is noted at SWI. It exerts mass effect in the form of moderate perifocal edema, compression upon left lateral ventricle, subfalcine herniation and midline shift by 1.5 cm. Mild hydrocephalic changes at the right lateral ventricle with CSF permeation near the occipital horn. The enhancing mural nodule inferiorly demonstrates reduced ADC values, lower than normal white matter. 

Case Discussion

The patient went on to have a resection.


Microscopic picture: Infiltrative richly cellular new growth composed of pleomorphic astrocytes having hyperchromatic nuclei with brisk mitotic activity. Areas of tumor necrosis observed. Glomeruloid vascular proliferation is noted. 

Diagnosis: Glioblastoma (WHO Grade IV).

Note: As IDH status, in this case, is unavailable, according to the current (2016) revision WHO classification of CNS tumors this tumor classified as a glioblastoma NOS.

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Case information

rID: 42051
Published: 18th Mar 2017
Last edited: 7th Dec 2018
Inclusion in quiz mode: Included

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