Glioblastoma NOS (multifocal)

Case contributed by Assoc Prof Frank Gaillard


Headaches and left sided weakness.

Patient Data

Age: 70 years
Gender: Male

A large mass involves the right temporal and occipital lobes. It is of high T2 signal with marked positive mass effect and has numerous enhancing components within it. There is involvement of the cortex and extension to the ependymal surface. On diffusion weighted imaging the enhancing components demonstrate restricted diffusion. 

Case Discussion

This case demonstrates typical appearances of a large glioblastoma (astrocytoma grade IV) which was confirmed on histology. It is important not to confuse a multifocal glioblastoma (single tumor with multiple regions of discrete enhancement embedded within it, with the much rarer multicentric glioblastoma, where enhancing foci are not linked together by tumor edema / non-enhancing tumor. 

Note: This case predates the recent (2016) revision WHO classification of CNS tumors and IDH status is not available. As such, this tumor would now be classified as a glioblastoma NOS.

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Case information

rID: 7783
Published: 7th Dec 2009
Last edited: 12th Oct 2020
Inclusion in quiz mode: Included

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