Glioblastoma NOS (multifocal)

Case contributed by Assoc Prof Frank Gaillard

Patient Data

Age: Adult

CT Brain

Mixed hypoattenuating and hyperattenuating changes are seen in the left hemisphere. 


MRI Brain

Multiple areas of contrast enhancement are present, some of which demonstrate central non-enhancement, are embedded in widespread high T2 signal change. Some of the enhancing components demonstrate restricted diffusion. 

Case Discussion

The patient went on to have surgery. 


Microscopic Description: Sections show a densely cellular glial neoplasm. The tumor cells have hyperchromatic, pleomorphic nuclei and abundant eosinophilic cytoplasm with fibrillary processes. There are areas where the tumor cells have scant cytoplasm and round nuclei that could represent focal oligodendroglial differentiation. Mitotic figures are frequent and there is abundant endothelial proliferation and tumor necrosis with pseudopalisading.

FINAL DIAGNOSIS: glioblastoma


Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 5367
Published: 8th Jan 2009
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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