Glioblastoma NOS (periventricular)

Case contributed by A.Prof Frank Gaillard

Irregular enhancing mass of the left splenium, left parietal lobe and left medial temporal lobe with surrounding vasogenic edema.

Case Discussion

The patient went on to have a biopsy. 

Histology

Microscopic Description:

Sections show pieces of a high-grade glioma displaying astrocytic characteristics predominantly. Areas of necrosis, including geographic areas of necrosis with nuclear pseudopalisading, are seen. Focal endothelial cell proliferation is observed. Some vessels display thrombotic occlusion of the lumen. Nuclear pleomorphism is increased. The tumour cells display, predominantly, astrocytic features. Mitotic figures are identified without difficulty.

FINAL DIAGNOSIS: glioblastoma

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 5644
Case created: 2nd Mar 2009
Last edited: 6th Jun 2017
Inclusion in quiz mode: Included

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