Glioblastoma NOS (splenium)

Case contributed by A.Prof Frank Gaillard

Large heterogeneously enhancing mass involving and thickening the splenium of the corpus callosum. Features are almost certainly those of a high-grade diffuse glioma (GBM most likely). Heterogeneity makes lymphoma less likely. 

Case Discussion

The patient underwent a biopsy.


Microscopic Description:

Sections show pieces of a high-grade glioma displaying astrocytic characteristics predominantly. Areas of necrosis, including geographic areas of necrosis with nuclear pseudopalisading, are seen. Focal endothelial cell proliferation is observed. Some vessels display thrombotic occlusion of the lumen. Nuclear pleomorphism is increased. The tumor cells display, predominantly, astrocytic features. Mitotic figures are identified without difficulty.

Final Diagnosis: Glioblastoma (WHO IV)

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS

PlayAdd to Share

Case information

rID: 5565
Published: 5th Feb 2009
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.