Glioblastoma NOS (splenium)

Case contributed by A.Prof Frank Gaillard
MRI

Large heterogeneously enhancing mass involving and thickening the splenium of the corpus callosum. Features are almost certainly those of a high-grade diffuse glioma (GBM most likely). Heterogeneity makes lymphoma less likely. 

Case Discussion

The patient underwent a biopsy.

Histology

Microscopic Description:

Sections show pieces of a high-grade glioma displaying astrocytic characteristics predominantly. Areas of necrosis, including geographic areas of necrosis with nuclear pseudopalisading, are seen. Focal endothelial cell proliferation is observed. Some vessels display thrombotic occlusion of the lumen. Nuclear pleomorphism is increased. The tumour cells display, predominantly, astrocytic features. Mitotic figures are identified without difficulty.

Final Diagnosis: Glioblastoma (WHO IV)

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a glioblastoma NOS

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Case information

rID: 5565
Published: 5th Feb 2009
Last edited: 18th Mar 2018
Inclusion in quiz mode: Included

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