Glioblastoma NOS (student teaching)

Case contributed by UoE Radiology


Three seizures in two weeks. Mild right sided weakness. No previous neurological history or known health conditions.

Patient Data

Age: 50
Gender: Female

Irregular hypodensity in left temporal lobe. Thickened hyperdense border which enhances with contrast. Some compression of lateral ventricle but no midline shift.

No hemorrhage or acute infarct. No extra-axial hemorrhage or collections. No bony injuries.


MRI for further study

Low signal from the center of the lesion in keeping with necrosis or central hemorrhage. Avid enhancement and high signal around the periphery with high signal surrounding this in keeping with vasogenic edema.

Case Discussion

This patient presented with new onset seizures and on imaging had an ill-defined enhancing mass on CT which had features in keeping with glioblastoma on MRI.

This diagnosis was confirmed with pathology following resection.

In patients with new seizures, with or without residual neurology, prompt imaging is strongly advised.


Thanks to Dr Hani Salam who contributed this case to The original case and further images can be found here.

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS


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Case information

rID: 37574
Published: 14th Jun 2015
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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