Glioblastoma - recurrent

Case contributed by Bahman Rasuli
Diagnosis certain


Intractable seizure and history of craniotomy 12 months ago.

Patient Data

Age: 60 years
Gender: Female

MRI demonstrates a large heterogenous signal intra-axial solid necrotic mass lesion in the left frontal and parietal-temporal lobes.

It exerts a significant mass effect with a midline shift, uncal herniation, compression of the left lateral ventricle occipital horn, and dilatation of the temporal horn, and is surrounded by vasogenic edema.

Invasion to the splenium of corpus callosum and midline cross of tumoral mass lesion is seen.

The lesion shows patches of diffusion restriction and heterogenous post-contrast enhancement.


The patient underwent brain tumor surgery one year ago. Biopsy confirmed this as a glioblastoma multiform, IDH wild type, WHO grade IV.

IHC results:

ATRX: positive

GFAP: positive

P53: positive

IDH1: negative

Case Discussion

The recent patient was referred with a flare-up of symptoms such as intractable seizure and headache.

Based above imaging findings, the recurrence of the known brain tumor should be considered.

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.