Glioblastoma with large cystic component

Case contributed by Dr Yune Kwong

Presentation

Referral from another institution for pre-surgical imaging.

Patient Data

Age: 57-year-old
Gender: Male

MRI Brain (selected images)

Modality: MRI

Large right temporal cystic/solid lesion with mass effect and compression of the right cerebral peduncle. Marginal rim enhancement around the margins of the cystic component. Solid elements on lateral margin, which enhance poorly and do not exhibit restricted diffusion.

Histology

MACROSCOPIC DESCRIPTION - Right temporal brain tumour: Multiple grey tan friable pieces of tissues measuring 40 x 30 x 10mm in aggregate.
MICROSCOPIC DESCRIPTION: A cellular infiltrate displaying variable nuclear hyperchromasia, angularity and pleomorphism, frequent mitotic figures and scant cell bodies, accompanied by a delicate fibrillary matrix which in part has a mucoid quality. Accompanied by a rich   vasculature,   including   thrombosis,   perivascular hyalinisation and swelling and stratification of endothelium, the infiltrate is diffuse but for foci of palisading around occasional blood vessels or zones of necrosis. The lesion appears to reach the subarachnoid space.  Part of the internal margin of the growth is present as a blurred interface with adjacent brain tissue.
DIAGNOSIS: Glioblastoma.

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Case Information

rID: 29580
Case created: 6th Jun 2014
Last edited: 11th Dec 2015
Inclusion in quiz mode: Included

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