Glioblastoma with subarachnoid spread

Case contributed by A.Prof Frank Gaillard
Modality: CT

Large enhancing lesion crossing the corpus callosum. 

Modality: MRI

Large butterfly glioma (crossing the corpus callosum) with extensive leptomeningeal enhancement, consistent with spread, seen not only in the intracranial compartment but also coating the cervical cord. 

Case Discussion

GBM with subarachnoid spread (note the encement along the brainstem)

Final Diagnosis:

Brain, bifrontal: Astrocytoma grade 4/4 using the Daumas-Duport grading system (glioblastoma multiforme with giant cell component).

Microscopic Description:

Sections show pieces of a high-grade glioma showing areas of necrosis, and vascular neogenesis. The tumour cells show astrocytic features with increased nuclear pleomorphism. A giant cell component is noted. Mitotic activity is increased. Bizarre mitotic figures are seen. Vascular neogenesis is seen. The tumour cells are strongly immunoreactive for GFAP.

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Case Information

rID: 5290
Case created: 31st Dec 2008
Last edited: 9th Jan 2016
Inclusion in quiz mode: Included

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