Gliomatosis cerebri

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: 40-50
MRI

MRI Brain

Select images from MRI study depicting multiple foci of T2/FLAIR cortical and white matter signal abnormalities involving the left parietal and occipital lobes, as well as the basal ganglia and insula. There is no contrast enhancement. 

Case Discussion

This patient underwent a brain biopsy that revealed: infiltrating glioma, consistent with gliomatosis cerebri.

Based upon the histologic features noted in the small biopsies, this glioma would only qualify as an astrocytoma grade II/IV using the Dumas-Duport grading system. Because of the diffuse pattern of infiltration, and sampling, this probably does not accurately reflect the actual grade of this malignant glioma.

Importantly, whereas gliomatosis was previously considered a distinct entity, since the 2016 update to the WHO classification of CNS tumours it is now merely thought of as a growth pattern.

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Case information

rID: 4367
Case created: 14th Aug 2008
Last edited: 21st Jul 2016
Tags: brain, tumour
Inclusion in quiz mode: Included

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