Gliomatosis cerebri

Case contributed by A.Prof Frank Gaillard




Case Discussion


Right frontal cortex and white matter: Diffusely infiltrating astrocytoma with a pattern consistent with gliomatosis cerebri (WHO Grade III).


The sections show a moderately cellular astrocytoma.  The astrocytes are unevenly distributed and they show enlarged hyperchromatic nuclei with mild pleomorphism.  The tumour cells extend into the cerebral cortex with perineuronal satellitosis.  One mitosis is seen.  There is no evidence of endothelial cell hyperplasia or necrosis.  The neuropil is focally oedematous and vacuolated. Many cells are p53 positive. The Ki-67 index is about 1%.

The features are those of diffusely infiltrating astrocytoma with a pattern consistent with gliomatosis cerebri. Most of these lesions are regarded as grade III.


Importantly, whereas gliomatosis was previously considered a distinct entity, since the 2016 update to the WHO classification of CNS tumours it is now merely thought of as a growth pattern.

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Case information

rID: 9934
Case created: 1st Jun 2010
Last edited: 21st Jul 2016
Inclusion in quiz mode: Included

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