Gliomatosis cerebri

Case contributed by Dr Vinay Shah


Difficulty in walking and weakness in all limbs.

Patient Data

Age: 55 years
Gender: Female

Multiple altered signal lesions are seen in the right anterior temporal cortex, right thalamus, bilateral cerebellar vermis region, right middle cerebellar peduncle, left frontal periventricular region. Associated coerical thickening with edema noted. The lesions shows variable enhancement form predominantly non-enhancemt  with few lesions show ring and nodular enhancement. The largest enhancing lesions measuring approx 2.2 x 1.7 cm at cerebellar vermis, 1.1 x 1.2 cm at right thalamus, 1.0 x 1.1 cm at right anterior temporal region. The lesion at the right thalamus shows ring enhancement. There is moderate perileasional edema seen at both thalamus, right temporal region and cerebellar region bilaterally.   

Case Discussion

These findings most likely represents diffuse gliomatosis cerebri

Other unlikely differential is demyelinating disease / ADEM. 


Importantly, whereas gliomatosis was previously considered a distinct entity, since the 2016 update to the WHO classification of CNS tumours it is now merely thought of as a growth pattern.

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Case information

rID: 20822
Published: 14th Dec 2012
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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