Gliosarcoma

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
MRI

Heterogeneously, but mainly peripherally, enhancing lesion in the parietal lobe, with extensive surrounding oedema and positive mass effect. Spectroscopy demonstrates elevated choline and depressed NAA. Elevation of rCBV (area under the curve) is seen in the solid component. 

Case Discussion

The patient went on to have a resection. 

Histology

Microscopic Description:

Sections show a glial tumour displaying necrosis, vascular proliferation, a spindle cell component (consistent with so-called gliosarcoma), and obvious mitotic activity. The tumour cells display features that range from small cell to gemistocytic characteristics. Blood vessels appear somewhat hyalinized in areas.

Final Diagnosis: gliosarcoma.

Note: This case predates the recent (2016) revision WHO classification of CNS tumours and IDH status is not available. 

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Case information

rID: 5322
Case created: 2nd Jan 2009
Last edited: 21st May 2017
Inclusion in quiz mode: Included

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