Gliosarcoma mimicking post-traumatic hemorrhage

Case contributed by Rajesh S


Adult male presented with a right-sided headache. Recent history of trauma 2 weeks ago was present.

Patient Data

Age: 60 years
Gender: Male

Non contrast CT


Focal hyperattenuating areas with intervening mixed densities are noted in the right temporal parenchyma along the right Sylvian fissure showing perilesional edema.

Thin SDH is noted along the right frontotemporal parietal convexity.

Early mass effect is noted in the form of effacement of sulci, fissures and right lateral ventricle causing midline shift of 4 mm to the left is noted.

Differentials: Ruptured MCA branch aneurysm/hemorrhagic space-occupying lesion.

Suggested CT cerebral angiogram for further evaluation.

CT cerebral angiography


CT angiography reveals displacement of the adjacent MCA vessels with no abnormal bulbosity or saccular outpouching. No abnormal vascular nidus was seen. Thus there was no imaging evidence of vascular abnormalities such as an aneurysm or AVM. It was decided to proceed with MRI to exclude non vascular causes.

There is a focal intraparenchymal hemorrhage which is isointense on T1 and heterointense on T2 in the right temporo-polar parenchyma. 

There is early mass effect with effacement of the right lateral ventricle and midline shift of 2 mm to the left side.

It shows few cystic areas and eccentric patchy enhancement most prominently seen on subtracted images along the anteroinferior aspect with gyriform pattern and adjacent dural involvement. Few other punctate areas of enhancement are also noted.

There is a thin SDH measuring 3 mm along the right cerebral convexity.

In view of delayed post-traumatic presentation, unusual imaging pattern with enhancement on subtracted images, and no obvious vascular abnormalities, we suggested histopathological correlation to exclude underlying neoplastic etiology / less likely other atypical infective etiologies. 

HPE confirmed the presence of an underlying high-grade spindle cell neoplasm along with the blood clot. IHC findings were in favor of gliosarcoma.

Case Discussion

This 60-year old male presented with a headache for 1 week. CT brain showed right temporal intraparenchymal hemorrhage with an isodense lesion at the center of hematoma, right frontotemporoparietal SDH, which suggests a ruptured right MCA branch aneurysm/hemorrhagic space-occupying lesion.

CT cerebral angiogram did not show any evidence of aneurysm/AVM. MRI brain showed a right temporal hemorrhagic neoplastic lesion. The patient underwent emergency right frontotemporoparietal decompressive craniectomy, excision of the right temporal lesion, evacuation of SDH and ICH.

Histopathology report revealed gliosarcoma. Angiosarcomatous components in gliosarcoma increase the risk of hemorrhage. 


Dr Shriram Varadharajan DM, Dr Meena Nedunchelian DNB, (Neuroradiology)

Dr Rajesh Shanker Iyer DM (Neurology),

Dr Suresh Jayabalan MCh (Neurosurgery) 

Dr Sangita S Mehta MD, Dr Rajeshwari MD (Pathology)

Kovai Medical Center & Hospital, Coimbatore, India

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