Ganular cell tumours were originally described
by Abrikossoff in 1926 and are usually found in the
mouth or skin but 6% occur in the breast. Up to 10% are multiple.
Incidence < 1 in a
1000 breast masses
Occurs from 20 – 80 but
around 40 years of age most common with slight preponderance in premenopausal
Usually less than
30mm in size, and are most frequently found in the upper inner
quadrant (supraclavicular nerve territory) followed by the axillary tail.
They are a neuroendocrine tumour
of perineural or Schwann cell origin that typically express S100 and CD68
At mammography - range from a round well-circumscribed mass, to
an indistinct or spiculated lesion. Microcalcifications are not usually a
At ultrasound, present
as solid, poorly marginated
lesions with marked posterior shadowing or as more benign-appearing well-circumscribed
solid masses. Lesion often have a reflective halo or are partially hyper-reflective
which is due its infiltrative growth pattern.