Granulomatosis with polyangiitis

Case contributed by Paul Leong
Diagnosis almost certain

Presentation

Unknown.

Patient Data

Age: 60 years
Gender: Female

Multiple pulmonary nodules. The nodules demonstrate central low density. There is also surrounding ground-glass density associated with some of these nodules.

Incidental right breast lesion. 

Case Discussion

Initial blood tests revealed a strongly positive c-ANCA.

A subsequent renal biopsy demonstrated necrotizing glomerulonephritis, with features consistent with granulomatosis with polyangiitis (previously known as Wegener's disease).

The significance and cause of the right breast mass is unknown. 

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