Granulomatosis with polyangiitis

Case contributed by Abdallah Al Khateeb
Diagnosis probable

Presentation

Worsening kidney function. Recent onset hemoptysis on a background of chronic cough. Longstanding paranasal sinus disease.

Patient Data

Age: 32 years old
Gender: Female

Sinuses CT

ct

Bilateral mucosal thickening with bony thinning. Perforation of the nasal septum is also seen.

Chest CT

ct

Few randomly scattered lung nodules are seen bilaterally, some show cavitary change with thick walls.

Case Discussion

The lung nodules seen in this case can be due to septic emboli, metastasis or vasculitis. The fact that the patient also has upper respiratory tract involvement, a positive c-ANCA lab result and probable renal system involvement, makes vasculitis in the form of Wegener granulomatosis the more likely diagnosis.

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