Granulomatous hypophysitis (Tubercular)

Case contributed by Keshaw Kumar
Diagnosis almost certain

Presentation

Headache and fever

Patient Data

Age: 15 years
Gender: Male
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Few small lytic areas in the basisphenoid/dorsum sellae.

The pituitary stalk appears mildly bulky.

The brain is otherwise unremarkable.

CEMRI Brain

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Homogeneously enhancing mildly bulky pituitary gland and pituitary stalk with normal size sella. There is the erosion and heterogenous enhancement of the clivus/dorsum sellae/basisphenoid associated with thick dural enhancement along the clivus. Oedema noted in bilateral optic tracts.

Small mucosal polyp in the sphenoid sinus.

Mild hypertrophy of adenoid.

Impression: Overall imaging findings are in favour of granulomatous hypophysitis

Case Discussion

The CSF study was done and the results are as follows-

Total leucocyte count: 220 cells/cumm.

Differential leucocyte count:

Neutrophils 10%

Lymphocytes: 90%

No immature / abnormal cells were seen.

RBC count: few

Glucose: 20 mg/dl (decreased).

Protein: 279 mg/dl (increased).

Chloride: 115 mmol/L (dereduced

---- The overall clinical history, imaging findings, and CSF study are in favour of Tubercular granulomatous hypophysitis.

Co-authors:

Dr. Mukund prasad, Mch (Neurosurgery).

Dr. Saket ballabh, DMRD, DNB (Radiodiagnosis).

Dr. Sanaullah mudassir, DM (Neuro medicine)

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