Graves disease (pathology)

Case contributed by Dr Andrew Ryan

Presentation

Presents with thyrotoxicosis.

Patient Data

Age: 30
Gender: Female
Pathology

Thyroid parenchyma with features of thyroid hyperactivity as seen in Graves disease with scalloping, partial follicular collapse and pseudopapillary infoldings.

Case Discussion

The hyperthryoid clinical state of Graves disease is the result of binding of auto-antibody to the TSH receptors of thyroid follicular cells with resultant activation of follicular cells, reabsorption of stored colloid and production and release of T3 and T4.

These photomicrographs demonstrate the pathophysiology in action with activated follicular epithelium and evidence of colloid reabsorption (seen as scalloping, partial follicle collapse and epithelial infoldings).  

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Case information

rID: 19449
Published: 11th Sep 2012
Last edited: 10th Apr 2018
System: Head & Neck
Inclusion in quiz mode: Excluded

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