Case contributed by Frank Gaillard
Diagnosis certain


Acute onset headache in a young man.

Patient Data

Age: Young adult
Gender: Male

MRI demonstrates a lesion in the cerebellum with central high T1 signal and heterogeneous T2 signal consistent with hemorrhage. Significant portions of the lesions enhance and large flow voids are present in the periphery. 

The features suggest a hemangioblastoma which was confirmed on resection. 

Case Discussion

The patient went on to have a resection.


Gross Description

The specimen consists of a rounded dark tan-dark red lesion measuring in maximum dimensions 3 x 3 x 2.8 cm. It is subsequently painted in black ink and serially sliced. The cut surfaces show a hemorrhagic dark tan lesion with cyst formation. Small representative fragments in the center of the lesion are placed in 2.5% glutaraldehyde. The remainder of the slices are submitted consecutively in blocks A1-A10 with A1 and A10 being the tips of the lesion, which are sectioned perpendicular to the remaining slices. Block A2 is used for Oil Red O stains, prior to processing for paraffin embedding.

Microscopic Description

Sections show the lesion is comprised of numerous small vessels, between which there are small round cells with eosinophilic cytoplasm, round nuclei with a minimal degree of pleomorphism. In some regions, these cells are arranged in sheets with little intervening blood vessels. Some large-diameter blood vessels are present in the lesion, some of which are thrombosed. Hemosiderin-laden macrophages are seen in some areas, which are sclerotic. Oil Red O stains on A2 show lipid droplets in some of the cells arranged in sheets. Immunohistochemistry shows that the tumor is negative for epithelial membrane antigen and keratin. Numerous CD31-positive blood vessels are seen within the lesion. Cerebellar tissue are seen adjacent to the lesion. This show varying degrees of gliosis, rarefaction of the granular layer, loss of Purkinje cells, and thinning of the molecular layer.

FINAL DIAGNOSIS: Haemantioblastoma

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