Case contributed by A.Prof Frank Gaillard



Patient Data

Age: 70
Gender: Female

A cystic mass in the right cerebellar hemisphere with an eccentric peripheral nodule is present, associated with some edema, but not obstructive hydrocephalus.  A number of prominent flow voids are present laterally, best seen on T2. 


The most likely diagnosis is that of a hemangioblastoma, although in this age group a metastasis should also be considered. 

Case Discussion


Paraffin sections show an intensely vascular moderately hypercellular tumor within cerebellum. Vascular spaces vary from large thin-walled sinusoidal structures down to thin-walled capillaries. The latter enclose lobules of cells with uniform round and oval vesicular nuclei and a variable amount of foamy cytoplasm. No mitotic figures or areas of necrosis are identified. Immunohistochemistry shows patchy moderately strong staining in tumor cells for Inhibin. No staining for CD10 or cytokeratins CAM5.2 or AE1/AE3 is seen in tumor cells. The features are of cerebellar capillary hemangioblastoma.

FINAL DIAGNOSIS: Right CP angle lesion: Capillary hemangioblastoma (WHO Grade 1).

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Case information

rID: 32093
Published: 25th Dec 2014
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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