Haemangiopericytoma

Case contributed by A.Prof Frank Gaillard

Presentation

Headache

Patient Data

Age: 65 years
Gender: Male
MRI

A large vividly enhancing but heterogeneous mass is seen on the left, abutting / arising form the tentorium and invaginating / extending into the undersurface of the occipital lobe. It is surrounded by cysts. ADC demonstrates facilitated diffusion compared to brain. Prominent flow voids are present. 

Case Discussion

The patient went on to have a resection. 

Histology

Paraffin sections show a densely hypercellular tumour. Tumour cells have moderately pleomorphic round, oval and angulated vesicular nuclei. Cytoplasmic boundaries are poorly defined. Tumour cells are aggregated in solid sheets with no specific architectural pattern discernible. However, in several areas, small calibre open vascular spaces are noted. These are lined by unremarkable endothelium. A moderately fibrous stroma is noted in several areas of the tumour. A very occasional mitotic figure is identified. There are no areas of necrosis. No evidence of invasion into brain parenchyma is seen. 

Immunohistochemistry shows strong staining of tumour cells for CD34 and bcl-2. There is also moderate nuclear staining for progesterone receptor (PgR). No staining for epithelial membrane antigen (EMA), cytokeratin AE1/AE3, GFAP, ALK-1 or tyrosinase is seen in tumour cells. The features are of haemangiopericytoma (WHO Grade II). The topoisomerase labelling index is <1%.

FINAL DIAGNOSIS: Haemangiopericytoma (WHO Grade II) 

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Case information

rID: 37606
Case created: 15th Jun 2015
Last edited: 4th Feb 2016
Inclusion in quiz mode: Included

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