Hemochromatosis (CNS manifestations)

Case contributed by Dr Hernán Brouver de Koning

Presentation

Ataxia and gait difficulty.

Patient Data

Age: 55 years
Gender: Male

The study is normal for age with small hyperdensities in globus pallidum commonly seen in this age group. 

T2*-weighted brain imaging shows striking extensively dark choroid plexus, not appreciated on conventional T2 fast spin echo sequence which appears unremarkable. No cerebellopontine angle masses or other focal abnormality. 

Subtle T1 bilateral hyperintensities in basal ganglia.

Markedly hypointense liver in T2 weighted images. Caudate and left lobe hypertrophy. Surface nodularity.

The images have characteristic features of a cirrhotic T2 hypointense liver consistent with hemochromatosis (histologically probed).

Case Discussion

T2* weighted brain MRI detects iron overloading in patients with hemochromatosis as consequence of uptake it from the blood.

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Case information

rID: 58617
Published: 17th Mar 2018
Last edited: 24th Jun 2018
Inclusion in quiz mode: Included

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