Presentation
Known history of hereditary multiple exostoses
Patient Data
Multiple exostoses projecting from the metaphyseal regions of the femora, tibias, and fibulas bilaterally, most noticeably around the knees.
Multiple exostoses projecting from the metaphyseal regions of the humeri, radii, and ulnas bilaterally, most noticeably in the distal region of the forearms.
Case Discussion
Hereditary multiple exostoses (HME) a.k.a. osteochondromatosis is an autosomal dominant disorder in which mutations cause the development of multiple osteochondromas during skeletal growth.
Malignant transformation, most commonly into chondrosarcomas, is a possible complication.
Because the true incidence of osteochondromas is likely to be underestimated, it is hard to compare the incidence of multiple osteochondromas vs isolated osteochondromas.