HIV associated leiomyosarcoma (intracranial)

Case contributed by Dr Trent Orton


HIV +ve (CD 4+ count / HAART etc.. unknown).

Patient Data

Age: 50 years
Gender: Male

Enhancing left middle cranial fossa mass, with wide dural attachment. 

Extra-axial mass with low T2 signal and vivid contrast enhancement. 

Case Discussion

The patient went on to have a craniotomy and resection. 


Microscopic Description:

Sections show a spindle cell neoplasm. It is composed of irregularly arranged fascicles of spindle cells. Areas of microcystic change are noted. Occasional areas of necrosis are present. There are occasional mitotic figures.

Immunohistochemistry shows positive staining for smooth muscle actin. The tumor is negative for CD34, CD31, GFAP and S-100 protein. The tumor is positive for caldesmon.

Electron microscopy shows the tumor is comprised of spindle cells with intermediate filaments. Many of these intermediate filaments undergo focal densifications, characteristic of smooth muscle cells. However, in addition, many of these tumor cells show fibronexus junctions, such as have been described in myofibroblasts.



This tumor was reviewed by Dr. [X], who has expertise in soft tissue tumors. He feels that this is a malignant tumor and that it is a leiomyosarcoma. He noted that such lesions have been described in patients infected with HIV and these are related to Epstein-Barr virus infection. He did immunohistochemical stains and these showed strong positive staining for caldesmon, a low MIB-1 index and strong positive staining throughout the lesion for Epstein-Barr virus in situ hybridization. There was negative staining for HHV8. These features would be in keeping with a leiomyosarcoma associated with an Epstein-Barr virus infection in immune-suppressed patient.


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Case information

rID: 4867
Published: 27th Oct 2008
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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