Huntington disease

Case contributed by Dr Mostafa Mahmoud El-Feky

Presentation

Chorea for investigation.

Patient Data

Age: 60
Gender: Male
MRI

MRI brain

The caudate nuclei are partially atrophied with a mildly widened intercaudate distance. Mild brain atrophic changes are also noted.

MRI

Measurements

The intercaudate distance to inner table ratio (CC:IT) is increased (0.194; N = 0.09-0.12) and frontal horn width to intercaudate ratio (FH:CC) is decreased (1.96; N = 2.2-2.6). 

Measurements have been taken at a slightly oblique angle as to compensate for the effect of head tilt, as to not have false measurements.

Case Discussion

Huntington disease is a neurodegenerative disease that affect the caudate nuclei. It is one of the causes of chorea as well as dementia, behavioral changes, and psychosis. Radiologically, the heads of caudate are atrophied with enlargement of the frontal horns, along with a more generalized cortical atrophy. Measurements that help to assess caudate atrophy include the intercaudate distance to inner table ratio (CC:IT) and the frontal horn width to intercaudate ratio (FH:CC). 

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Case information

rID: 56374
Published: 20th Dec 2017
Last edited: 21st Dec 2017
Inclusion in quiz mode: Included
Institution: Dar El Ashaa Center

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