Hypertriglyceridaemia-induced acute pancreatitis
12 hours of acute onset left flank pain.
Loading Stack -
0 images remaining
The patient proceeded to further work-up including ultrasound that did not demonstrate cholelithiasis was well as blood tests with selected results shown:
- Lipase: 519 IU/L (normal 8-78)
Fasting lipid profile:
- Cholest. 17.9H mmol/L (normal <4.0)
- HDLC 0.4L mmol/L (normal >1.0)
- Triglycer. 32.3H mmol/L (normal <1.5)
The patient also denied alcohol abuse.
Hypertriglyceridaemia is one of more common non-biliary non-alcoholic pancreatitis (meaning that is quite uncommon overall!), and is the most common (~55%) cause of pancreatitis in pregnancy.
While the pathogenesis is unclear, to induce pancreatitis serum triglyceride levels have to be at least 10 mmol/L and are typically >20 mmol/L. The underlying cause of hypertriglyceridaemia is most commonly (~60%) a genetic disorder in lipid metabolism.
- Sunnapwar A, Prasad SR, Menias CO et-al. Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum. AJR Am J Roentgenol. 2010;195 (1): 67-75. doi:10.2214/AJR.09.4048 - Pubmed citation
- Gan SI, Edwards AL, Symonds CJ et-al. Hypertriglyceridemia-induced pancreatitis: A case-based review. World J. Gastroenterol. 2007;12 (44): 7197-202. Free text at pubmed - Pubmed citation