Hypoglycaemic / seizure related neonatal encephalopathy
Hypoglycaemic, prolonged (2 hours) seizures.
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Marked diffusion restriction is seen throughout the cortex, sparing the basal ganglia and posterior fossa.
The pattern of brain injury in paediatric patients is complicated and varies considerably depending on duration, severity and underlying cause of insult. In the setting of pure hypoglycaemic neonatal encephalopathy, the occipital cortex and thalami are particularly involved. In this case however, the hypoglycaemia is combined with the changes from prolonged seizure which predominantly affects the supratentorial cortex.