Hypoxic-ischemic brain injury in a full term infant

Case contributed by Dr Dalia Ibrahim


Delayed mental and motor milestones. History of severe birth asphyxia.

Patient Data

Gender: Male

Bilateral hyperintense signal are seen at basal ganglia, thalami and perirolandic cortex.


Case Discussion

Severe asphyxia in term neonates result in injury involving the deep gray matter (putamina, ventrolateral thalami, hippocampi, dorsal brainstem, and lateral geniculate nuclei) and occasionally the perirolandic cortex.

These areas of the brain are actively myelinating (an energy-intensive process) or contain the highest concentrations of NMDA receptors at term and are, therefore, the most susceptible to neonatal hypoxic ischemic insult.

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Case information

rID: 53498
Published: 21st May 2017
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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