Immunotherapy-mediated colitis

Case contributed by Ryan Thibodeau
Diagnosis almost certain


History of metastatic melanoma, status post two cycles of immunotherapy. Third cycle postponed secondary to loose stools.

Patient Data

Age: 55 years
Gender: Male

Lower thorax:

Case Discussion

This case is highly suggestive of pancolitis and distal enteritis caused by ipilimumab, an immunotherapy medication. The patient had a prior study before commencing ipilimumab, which demonstrated metastatic melanoma to the lungs. While the disease burden within the lungs improved after two cycles (not shown on this case), the patient began to experience profuse, watery stools. Ipilimumab is known to cause colitis 1.

Camille Dumas, DO
Christine Cooley, MD

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