75 year old male presents with worsening dyspnoea on exertion. Pericardial effusion on transthoracic echocardiagram ordered by his local GP. CT imaging post pericardial drain insertion.
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The heart is enlarged. There is a pericardial drain in situ. There is a small residual pericardial effusion measuring up to 1.9 cm in depth. There is a large lobulated mass in the anterior mediastinum, measuring 8.6 x 6.7 x 6.6 cm (transverse by AP by caudocranial dimensions). It is composed mainly of material of soft tissue density with small foci of calcification centrally measuring up to 1.2 cm. The mass probably invades the anterosuperior pericardium, and is closely related to the deepest pocket of the pericardial effusion. The mass also abuts the anterior surface of the left brachiocephalic vein, but does not cause significant compression.
There are small bilateral pleural effusions with minimal bibasal compressive atelectasis.
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Thymomas, while rare, are the most common primary tumors of the mediastinum 1. They arise from thymic tissue. Most patients are between 40 to 60 years of age with an annual incidence of 0.15 per 100,000 person years 1, 2. There is a strong association with myasthenia gravis and paraneoplastic syndromes2.
Yellow adipose tissue 220 x 170 x 75 mm, 513 g, containing a firm multinodular tumor. On one side the specimen is lined by a shiny smooth membranous pericardial surface with multiple bulging exophytic brown nodules.
Sectioning reveals a variegated solid pale pink tumor 90 x 75 x 50 mm which extends to involve the roughened area of resection, together with multiple solid dark brown nodules up to 30 mm. No necrosis or hemorrhage is seen. The thymic fat shows yellow adipose tissue with several 5-10 mm tumor nodules immediately adjacent to the main tumor
Invasive thymoma. WHO Types A & B3. 90 mm maximum dimension and incompletely excised. Involves chest wall inked resection surface over a distance of at least 10 mm. Tumor bulges into pericardial cavity but with intact pericardium. Lymphatic invasion identified. No perineural invasion identified.
- 1. Tomaszek S, Wigle DA, Keshavjee S, Fischer S. Thymomas: review of current clinical practice. Ann Thorac Surg. 2009 Jun;87(6):1973-80. doi: 10.1016/j.athoracsur.2008.12.095.
- 2. Rashid OM, Cassano AD, Takabe K. Thymic neoplasm: a rare disease with a complex clinical presentation. J Thorac Dis. 2013 Apr;5(2):173-83. doi: 10.3978/j.issn.2072-1439.2013.01.12.