JC virus granule cell neuronopathy

Case contributed by Estibaliz Onís González
Diagnosis almost certain

Presentation

Recent HIV infection diagnosis. Gait instability and feeling of progressive dizziness for 2 months.

Patient Data

Age: 60 years
Gender: Male

Diffuse and symmetrical cerebellar atrophy.

Bilateral swelling and T2-FLAIR hyperintensity of cerebellar peduncles that extends towards cerebellar hemispheres.

Cruciform T2-FLAIR signal hyperintensity of the pons (hot cross bun sign).

Case Discussion

JC virus PCR assay was positive.

The case is consistent with JC virus granule cell neuronopathy.

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