Presentation
Delayed developmental milestones.
Patient Data
Age: 8 months
Gender: Female
From the case:
Krabbe disease
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Info
Bilateral symmetrical confluent signal abnormality involving centrum semiovale, corona radiata, peritrigonal region, posterior limb of internal capsule, brainstem and dentate nuclei of cerebellum appearing low on TIWI, high on T2WI without diffusion restriction on DWI and ADC mapping.
Case Discussion
As opposed to main differential diagnosis of metachromatic leukoystrophy, krabbe disease initially shows symmetrical involvement of thalami, caudate nuclei, cerebellum,posterior limb of internal capsule and brainstem which later on extend to centrum semiovale / corona radiata.
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