L-asparaginase induced pancreatitis in childhood acute lymphoblastic leukemia
Citation, DOI, disclosures and case data
Sorrentino S, L-asparaginase induced pancreatitis in childhood acute lymphoblastic leukemia. Case study, Radiopaedia.org (Accessed on 20 Mar 2023) https://doi.org/10.53347/rID-20164
At the time the case was submitted for publication Sajoscha A. Sorrentino had no recorded disclosures.View Sajoscha A. Sorrentino's current disclosures
5 Nov 2012
16 times, by 4 contributors - see full revision history and disclosures
Background of childhood acute lymphoblastic leukemia, with elevated amylase and lipase.
Age: 10 years
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C+ portal venous phase
Enlarged pancreas and peripancreatic fluid in the lesser sac and left pararenal space.
L-asparaginase has been part of the treatment of childhood onset ALL for many decades now. L-asparaginase induced pancreatitis is known to be a major complication of this treatment, but the pathophysiology behind this is still to be found.
- Raja RA, Schmiegelow K, Frandsen TL. Asparaginase-associated pancreatitis in children. Br. J. Haematol. 2012;159 (1): 18-27. doi:10.1111/bjh.12016 - Pubmed citation