Liver metastases - low density

Case contributed by A.Prof Frank Gaillard

Presentation

Constitutional symptoms in a 60 year old female

Patient Data

Age: 60
Gender: Female
Modality: CT

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Case Discussion

Section show a good-size needle core  biopsy of liver parenchyma containing  a deposit of  malignant  tumour.  The  tumour  comprises large  epithelioid  cells arranged  in  solid nests.   The cells  have moderately  to markedly  pleomorphic nuclei, small nucleoli,  and abundant basophilic cytoplasm.  No clear cut features  of specific differentiation are  identified in the H&E  sections   (no   definite    gland   formation,    mucin   production,   or  keratinisation).   The tumour  is partly necrotic.  The  peritumoral liver parenchyma shows non-specific changes consistent with a proximity to a mass lesion, as well as mild macrovesicular steatosis.

The  lesion  is  most  likely   metastatic    non-small   cell   carcinoma. Immunohistochemical stains  underway to further  assess the differentiation of the lesion  and  possible  primary sites  of origin.   

Diagnosis

Liver biopsy  - large cell  malignant  neoplasm,  most likely representing  metastatic     poorly     differentiated     non-small   cell   carcinoma.

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Case Information

rID: 10650
Case created: 31st Aug 2010
Last edited: 14th Oct 2016
Inclusion in quiz mode: Included

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