Malignant fibrous histiocytoma of the breast

Case contributed by Dr Giorgio M Baratelli

Patient Data

Age: 75 years
Gender: Female

Mammograms show a round, dense mass with fine spiculated margins.

A wide local excision with tumor-free margins and a sentinel node biopsy was performed.

The final histology showed a high grade spindle cell tumor, with marked nuclear atypia and 10 mitotic figures per 10 hpf. The value of Ki-67 labeling index was 35 % .

The sentinel node was negative for metastases.

The neoplastic cells were negative for desmin, CD34, CKAE1/AE3, CK34bE12, calponina and positive for AML and vimentin.

Case Discussion

Primary malignant fibrous histiocytoma (MFH) of the female breast occurs very rarely, less than 1% of all breast malignancies

At 5-year follow-up, the patient is alive and well without evidence of disease.

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Case information

rID: 39110
Published: 20th Aug 2015
Last edited: 28th Nov 2015
System: Breast
Inclusion in quiz mode: Included

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